Study: Stem cells from strangers can repair hearts

LOS ANGELES (AP) — Researchers are reporting a key advance in using stem cells to repair hearts damaged by heart attacks. In a study, stem cells donated by strangers proved as safe and effective as patients' own cells for helping restore heart tissue.

The work involved just 30 patients in Miami and Baltimore, but it proves the concept that anyone's cells can be used to treat such cases. Doctors are excited because this suggests that stem cells could be banked for off-the-shelf use after heart attacks, just as blood is kept on hand now.

Results were discussed Monday at an American Heart Association conference in California and published in the Journal of the American Medical Association.

The study used a specific type of stem cells from bone marrow that researchers believed would not be rejected by recipients. Unlike other cells, these lack a key feature on their surface that makes the immune system see them as foreign tissue and attack them, explained the study's leader, Dr. Joshua Hare of the University of Miami.

The patients in the study had suffered heart attacks years earlier, some as long as 30 years ago. All had developed heart failure because the scar tissue from the heart attack had weakened their hearts so much that they grew large and flabby, unable to pump blood effectively.

Researchers advertised for people to supply marrow, which is removed using a needle into a hip bone. The cells were taken from the marrow and amplified for about a month in a lab at Baltimore's Johns Hopkins University, then returned to Miami to be used for treatment, which did not involve surgery.

The cells were delivered through a tube pushed through a groin artery into the heart near the scarred area. Fifteen patients were given cells from their own marrow and 15 others, cells from strangers.

About a year later, scar tissue had been reduced by about one-third. Both groups had improvements in how far they could walk and in quality of life. There was no significant difference in one measure of how well their hearts were able to pump blood, but doctors hope these patients will continue to improve over time, or that refinements in treatment will lead to better results.

The big attraction is being able to use cells supplied by others, with no blood or tissue matching needed.

"You could have the cells ready to go in the blood bank so when the patient comes in for a therapy — there's no delay," Hare said. "It's also cheaper to make the donor cells," and a single marrow donor can supply enough cells to treat as many as 10 people.

Dr. Elliott Antman of Harvard-affiliated Brigham and Women's Hospital in Boston who heads the heart conference, praised the work.

"That opens up an entire new avenue for stem cell therapy, like a sophisticated version of a blood bank," he said. There's an advantage in not having to create a cell therapy for each patient, and it could spare them the pain and wait of having their own marrow harvested, he said.

The study was sponsored by the National Institutes of Health. Hare owns stock in a biotech company working on a treatment using a mixture of cells.

Juan Lopez received his own cells in the study, and said it improved his symptoms so much that at age 70, he was able to return to his job as an engineer and sales manager for a roofing manufacturer and ride an exercise bike.

"It has been a life-changing experience," said Lopez, who lives in Miami. "I can feel day by day, week by week, month by month, my improvement. I don't have any shortness of breath and my energy level is way up there. I don't have any fluid in my lungs."

And, he said happily, "My sex drive has improved!"

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP .

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Obama's lease renewed despite tough economic times

WASHINGTON (AP) — His lease renewed in trying economic times, President Barack Obama claimed a second term from an incredibly divided electorate and immediately braced for daunting challenges and progress that comes only in fits and starts.


"We have fought our way back and we know in our hearts that for the United States of America, the best is yet to come," Obama said.


The same voters who gave Obama another four years also elected a divided Congress, re-upping the dynamic that has made it so hard for the president to advance his agenda. Democrats retained control of the Senate; Republicans renewed their majority in the House.


It was a sweet victory for Obama, but nothing like the jubilant celebration of four years earlier, when his hope-and-change election as the nation's first black president captivated the world. This time, Obama ground out his win with a stay-the-course pitch that essentially boiled down to a plea for more time to make things right and a hope that Congress will be more accommodating than in the past.


The vanquished Republican, Mitt Romney, tried to set a more conciliatory tone on the way off the stage.


"At a time like this, we can't risk partisan bickering," Romney said after a campaign filled with it. "Our leaders have to reach across the aisle to do the people's work."


House Speaker John Boehner spoke of a dual mandate, saying, "If there is a mandate, it is a mandate for both parties to find common ground and take steps together to help our economy grow and create jobs."


Senate Republican Leader Mitch McConnell had a more harsh assessment.


"The voters have not endorsed the failures or excesses of the president's first term," McConnell said. "They have simply given him more time to finish the job they asked him to do together" with a balanced Congress.


Obama claimed a commanding electoral mandate — at least 303 electoral votes to 206 for Romney — and had a near-sweep of the nine most hotly contested battleground states.

But the close breakdown in the popular vote showed Americans' differences over how best to meet the nation's challenges. With more than 90 percent of precincts reporting, the popular vote went 50 percent for Obama to 48.4 percent for Romney, the businessman-turned-politician who had argued that Obama had failed to turn around the economy and said it was time for a new approach keyed to lower taxes and a less intrusive government.


Obama's re-election assured certainty on some fronts: His signature health-care overhaul will endure, as will the Wall Street reforms enacted after the economic meltdown. The drawdown of troops in Afghanistan will continue apace. And with an aging Supreme Court, the president is likely to have at least one more nomination to the high court.


The challenges immediately ahead for the 44th president are all too familiar: an economy still baby-stepping its way toward full health, 23 million Americans still out of work or in search of better jobs, civil war in Syria, an ominous standoff over Iran's nuclear program, and more.


Sharp differences with Republicans in Congress on taxes, spending, deficit reduction, immigration and more await.


And even before Obama gets to his second inaugural on Jan. 20, he must grapple with the threatened "fiscal cliff" — a combination of automatic tax increases and steep across-the-board spending cuts that are set to take effect in January if Washington doesn't quickly come up with a workaround budget deal. Economists have warned the economy could tip back into recession absent a deal.


Despite long lines at polls in many places, turnout overall looked to be down from four years ago as the president pieced together a winning coalition of women, young people, minorities and lower-income voters that reflected the country's changing demographics. Obama's superior ground organization in the battleground states was key to his success.


The president's victory speech — he'd written a concession, too, just in case — reflected the realities of the rough road ahead.


"By itself the recognition that we have common hopes and dreams won't end all the gridlock, or solve all our problems or substitute for the painstaking work of building consensus and making the difficult compromises needed to move this country forward," Obama said.


"But that common bond is where we must begin. Our economy is recovering. A decade of war is ending. A long campaign is now over, and whether I earned your vote or not, I have listened to you, I have learned from you and you have made me a better president."


The president said he hoped to meet with Romney and discuss how they can work together. They may have battled fiercely, he said, "but it's only because we love this country deeply."


Romney's short concession — with misplaced confidence, he'd only prepared an acceptance speech — was a gracious end note after a grueling campaign.


He wished the president's family well and told subdued supporters in Boston, "I so wish that I had been able to fulfill your hopes to lead the country in a different direction, but the nation chose another leader and so Ann and I join with you to earnestly pray for him and for this great nation."


Obama's re-election was a remarkable achievement given that Americans are anything but enthusiastic about the state they're in: Only about 4 in 10 voters thought the economy is getting better, just one quarter thought they're better off financially than four years ago and a little more than half think the country is on the wrong track, exit polls showed.


But even now, four years after George W. Bush left office, voters were more likely to blame Bush than Obama for the fix they're in.


It wasn't just the president and Congress who were on the ballot. Voters around the country considered ballot measures on a number of divisive social issues, with Maine and Maryland becoming the first states to approve same-sex marriage by popular vote while Washington state and Colorado legalized recreational use of marijuana.


From the beginning, Obama had an easier path than Romney to the 270 electoral votes needed for victory. The most expensive campaign in history was narrowly targeted at people in nine battleground states that held the key to victory, and the two sides drenched voters there with more than a million ads, the overwhelming share of them negative.


Obama claimed at least seven of the battleground states, most notably Ohio, the Ground Zero of campaign 2012. He also got Iowa, New Hampshire, Colorado, Nevada, Virginia and Wisconsin, and he was ahead in Florida. Romney got North Carolina.


Overall, Obama won 25 states and the District of Columbia and was leading in too-close-to-call Florida. Romney won 24 states.


It was a more measured victory than four years ago, when Obama claimed 365 electoral votes to McCain's 173, winning with 53 percent of the popular vote.


Obama was judged by 53 percent of voters to be more in touch with people like them. More good news for him: Six in 10 voters said that taxes should be increased. And nearly half of voters said taxes should be increased on income over $250,000, as Obama has called for.


Obama's list of promises to keep includes many holdovers he was unable to deliver on in his first term: rolling back tax cuts for upper-income people, immigration reform, reducing federal deficits, and more.


A second term is sure to produce turnover in his Cabinet: Treasury Secretary Timothy Geithner has made it clear he wants to leave at the end of Obama's first term but is expected to remain in the post until a successor is confirmed. Secretary of State Hillary Rodham Clinton, Obama's rival for the presidency four years ago, is ready to leave too. Defense Secretary Leon Panetta isn't expected to stay on.


To the end, the presidential race was a nail-biter. About 1 in 10 voters said they'd only settled on their presidential choice within the last few days or even on Election Day, and they were closely divided between Obama and Romney. Nearly 1 percent of voters went for Libertarian Party candidate Gary Johnson, who was on the ballot in 48 states.


In an election offering sharply different views on the role of government, voters ultimately narrowly tilted toward Obama's approach.


"We have seen growth in the economy," said 25-year-old Matt Wieczorek, a registered Republican from Cincinnati who backed the president. "Maybe not as fast as we want it to be, but Obama has made a difference and I don't want to see that growth come to an end."


Notwithstanding his victory, Obama will lead a nation with plenty of people who were ready for a change.


"The last four years have been crap," said 73-year-old Marvin Cleveland, a Romney supporter in Roseville, Minn. "Let's try something else."


___


Follow Nancy Benac on Twitter: http://www.twitter.com/nbenac

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China hauls away activists in congress crackdown

BEIJING (AP) — During her 30-hour train journey to Beijing, Wang Xiulan ducked into bathrooms whenever the conductors checked IDs. Later, as she lay low in the outskirts of the capital, unidentified men caught her in a nighttime raid and hauled her to a police station. She assumed a fake identity to get away, and is now in hiding again.

Wang's not a criminal. She's a petitioner.

She's among many people attempting to bring local complaints directly to the central government in an age-old Chinese tradition that has continued during the Communist Party era. But police never make that easy, and this week, as an all-important leadership transition begins, a dragnet is aimed at keeping anyone perceived as a threat or a troublemaker out of Beijing.

"There is no law in China, especially for us petitioners and ordinary folk," Wang, 50, said in an interview with The Associated Press. "Even common gangsters and hoodlums get to leave after they serve time for crimes, but for us, if we get locked up, we never know when we might be freed."

Authorities want no surprises as the handover of power begins in the capital Thursday. The transition already has been rocked by the party's messiest scandal in decades, involving a former high-flying politician now accused of engaging in graft and obstructing the investigation into his wife's murder of a British businessman.

Rights groups say the wide-ranging crackdown on critics bodes poorly for those who hope the incoming generation of leaders will loosen restrictions on activism.

"China's top political leaders are very nervous, as they have since early this year been consumed by one of the most destabilizing and disharmonious power struggles in decades," said Renee Xia, international director of the Chinese Human Rights Defenders. The group estimates that hundreds or thousands of people have come under some kind of restriction in preparation for the party congress.

Lawyers have been held under illegal house arrest, dissidents sent back to their hometowns and activists questioned. Internet users report difficulties accessing many websites and the failure of software meant to bypass Internet filters.

Veteran activist Huang Qi, who runs a website on petitioners like Wang, said nearly 1,000 people have contacted him over the past few weeks to complain that authorities have hired thugs to harass and beat them.

"I hope that the Chinese authorities will face up to the social problems," Huang said in an interview. "Using violence will only escalate the resistance."

The crackdown reflects the leadership's nervousness as slowing economic growth exacerbates public outrage over corruption, social injustice, pollution and favoritism toward state-run agencies and the elite at the expense of ordinary people.

Under normal circumstances, petitioners are relatively safe once they reach Beijing's outskirts, though in their home provinces they are almost perpetually on the run from hostile local officials or thugs-for-hire who want to nab them before they can get an audience with central government agencies.

Now, however, even the capital's fringes are off limits.

Wang, a petite woman with shoulder-length hair neatly tied back, has been trying for two decades to draw central government attention to what she says was police mishandling of a serious assault she suffered in her native Harbin. Not only did her attacker go unpunished, but Wang ended up getting dismissed from her job years later.

Wang arrived in late October in Lu Village in Beijing's southwest, where petitioners have sought refuge for years. A police post guards the road into the village, and residents say officers have lately blocked petitioners from entering.

Wang had rented a bed — a wooden plank on bricks — in a tiny concrete room shared with two others. A gang of two dozen men barged in one night at 11 p.m., demanded to see her ID, searched her belongings and grabbed her cellphone.

"I was scared to death when they suddenly barged in here," Wang said, pointing at the door, where the lock had just been replaced.

The men refused to identify themselves and bundled her into a minivan with other petitioners. At another stop, she saw a couple dragged into the vans in their pajamas, the woman wearing only one shoe.

All were taken to a police station in nearby Jiujingzhuang village, where many petitioners say police process them for return to their hometowns. Using someone else's identity, Wang was able to evade police suspicion and was released. Many of the others were sent back, she said.

The raids are having an effect. The compound that houses her room and others now has only a handful of residents, down from about 30.

"They've all been chased away, caught or scared home," said Liu Zhifa, a 67-year-old petitioner from Henan province and one of the holdouts. Liu confirmed Wang's description of the Oct. 31 raid and described his own encounter with thugs breaking his lock and entering his room three times in one night in mid-October.

"I asked them to show their identifications, and they yelled at me, saying 'What right do you have to see our identification? Who do you think you are?" said Liu. "They were ruthless. The authorities and the police are working with people in the underworld."

A police officer who would only give his surname, Wei, answered the phone at a Jiujingzhuang police station (not 'the' because the police station has another name) and denied that authorities were raiding petitioners' villages. "We only act according to the law," Wei said. Questions about the broader crackdown were referred to the Beijing public security bureau, which did not respond to faxed questions.

The crackdown has extended to lawyers such as Xu Zhiyong. He said Beijing authorities have held him under informal house arrest since mid-October, stationing four or five guards outside his apartment in Beijing around the clock.

Xu has campaigned for years against Chinese authorities' use of "black jails," or unofficial detention centers run by local governments to hold petitioners. The government has denied the existence of such facilities, but even the tightly controlled state media have reported on them.

"The illegal restriction of a citizen's personal freedom for a long period of time is criminal behavior," Xu wrote in an email. "In an authoritarian state, this type of crime takes place everywhere."

Authorities in Shanghai also have ratcheted up pressure on critics, sentencing veteran women's rights activist Mao Hengfeng to a year and a half of labor camp. Mao, accused of disturbing social order, had been detained in Beijing in late September, said her husband, Wu Xuewei, who indicated she was being put away to silence her before the party congress.

Even dissidents' relatives have come under pressure. Beijing activist Hu Jia said he was warned by police to leave town, and that even his parents told him that police had told them to escort him to his hometown.

"My parents said to me: 'Hu Jia, you don't know what kind of danger you are in, but we know,'" he recounted in a phone interview from his parents' home in eastern Anhui province. "They said: 'Beijing is a cruel battlefield. If you stay here, you will be the first to be sacrificed. Don't do this.'"

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Follow Gillian Wong on Twitter at twitter.com/gillianwong

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Bruno Mars: 'SNL' can call me whenever they want

NEW YORK (AP) — Bruno Mars' recent appearance on "Saturday Night Live" was more like "Saturday Night Fever": He says he had so much fun hosting the show, he'd be happy to do it again.

"Whatever 'SNL' wants from me, they can always call me," the smiling 27-year-old said in an interview. "I don't know who told them I can act or anything 'cause I can't. I don't know what they saw. (But) whatever they need from me, they can get."

The singer-songwriter's Oct. 20 appearance as host and musical guest gave the NBC variety show its second best ratings this season behind last week's episode, hosted by comedian Louis C.K.

Mars was praised for his hilarious and silly sketches, particularly one skit where he did impersonations of other musicians as a live fill-in at Pandora when the company's computers crashed.

"It was kind of a way for me to face my fears and just let it all hang loose, literally," he said, laughing. "People don't understand that they're changing things right before the show, so you can't memorize lines because they're going to change it. They cut sketches and it's an amazing operation. I wouldn't trade that experience for the world."

The Grammy winner says he watched the show days after it aired live, and that's when things started to sink in, especially seeing himself dressed as a woman.

"I was like, 'Oh my god,'" he said, adding with a laugh: "Called my mom, 'Mom!'"

The "SNL" success is giving Mars a boost as he readies the release of his sophomore album, "Unorthodox Jukebox," out Dec. 11. It features Esperanza Spalding, Mark Ronson, Jeff Bhasker, Diplo, Paul Epworth and others.

On "SNL," he debuted a new song, "Young Girls," and performed his current single, the upbeat "Locked Out of Heaven." It's his 12th Top 10 hit on the Billboard Hot 100 chart as a performer, songwriter or producer.

"I love ('Locked Out of Heaven') because it's different ... than what you're used to hearing me maybe sing normally," he said.

___

Online:

http://www.brunomars.com

http://www.nbc.com/saturday-night-live/

___

Follow Mesfin Fekadu on Twitter at http://twitter.com/musicmesfin .

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Study: Stem cells from strangers can repair hearts

LOS ANGELES (AP) — Researchers are reporting a key advance in using stem cells to repair hearts damaged by heart attacks. In a study, stem cells donated by strangers proved as safe and effective as patients' own cells for helping restore heart tissue.

The work involved just 30 patients in Miami and Baltimore, but it proves the concept that anyone's cells can be used to treat such cases. Doctors are excited because this suggests that stem cells could be banked for off-the-shelf use after heart attacks, just as blood is kept on hand now.

Results were discussed Monday at an American Heart Association conference in California and published in the Journal of the American Medical Association.

The study used a specific type of stem cells from bone marrow that researchers believed would not be rejected by recipients. Unlike other cells, these lack a key feature on their surface that makes the immune system see them as foreign tissue and attack them, explained the study's leader, Dr. Joshua Hare of the University of Miami.

The patients in the study had suffered heart attacks years earlier, some as long as 30 years ago. All had developed heart failure because the scar tissue from the heart attack had weakened their hearts so much that they grew large and flabby, unable to pump blood effectively.

Researchers advertised for people to supply marrow, which is removed using a needle into a hip bone. The cells were taken from the marrow and amplified for about a month in a lab at Baltimore's Johns Hopkins University, then returned to Miami to be used for treatment, which did not involve surgery.

The cells were delivered through a tube pushed through a groin artery into the heart near the scarred area. Fifteen patients were given cells from their own marrow and 15 others, cells from strangers.

About a year later, scar tissue had been reduced by about one-third. Both groups had improvements in how far they could walk and in quality of life. There was no significant difference in one measure of how well their hearts were able to pump blood, but doctors hope these patients will continue to improve over time, or that refinements in treatment will lead to better results.

The big attraction is being able to use cells supplied by others, with no blood or tissue matching needed.

"You could have the cells ready to go in the blood bank so when the patient comes in for a therapy — there's no delay," Hare said. "It's also cheaper to make the donor cells," and a single marrow donor can supply enough cells to treat as many as 10 people.

Dr. Elliott Antman of Harvard-affiliated Brigham and Women's Hospital in Boston who heads the heart conference, praised the work.

"That opens up an entire new avenue for stem cell therapy, like a sophisticated version of a blood bank," he said. There's an advantage in not having to create a cell therapy for each patient, and it could spare them the pain and wait of having their own marrow harvested, he said.

The study was sponsored by the National Institutes of Health. Hare owns stock in a biotech company working on a treatment using a mixture of cells.

Juan Lopez received his own cells in the study, and said it improved his symptoms so much that at age 70, he was able to return to his job as an engineer and sales manager for a roofing manufacturer and ride an exercise bike.

"It has been a life-changing experience," said Lopez, who lives in Miami. "I can feel day by day, week by week, month by month, my improvement. I don't have any shortness of breath and my energy level is way up there. I don't have any fluid in my lungs."

And, he said happily, "My sex drive has improved!"

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP .

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Election 2012: You're in the Control Room

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    It is a fact of any election: there must be a loser. On Wednesday morning, either Mitt Romney or Barack Obama will wake up to the realization that he will not be spending the next four years in the Oval Office. Those plans for the transition? Throw them in the trash.Read More

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    Several athletes have made the jump to politics, including Jack Kemp (NFL, vice-presidential candidate in 1996), Jim Bunning (baseball, U.S. senator) and Bill Bradley (NBA, U.S. senator). More recently, Kevin Johnson (formerly of the Phoenix Suns) and Heath Shuler (formerly of the Washington Redskins) have made the leap into the political arena.Read More

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    In the bitterly fought battle for women voters this election season, both candidates dwelled on issues like equal pay, abortion, access to contraception and women's unemployment. And the news media eagerly speculated on the candidates' chance of success with female voters, who made up 53 percent of the electorate in 2008.Read More

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    NEW YORK (AP) - Election Day turnout was heavy in several storm-ravaged areas in New York and New Jersey, with many voters expressing relief and even elation at being able to vote at all, considering the devastation.Read More

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    From Yahoo! News: BEDFORD, Mass. - Mitt and Ann Romney cast their ballots this morning, the candidate saying that he's feeling "very good" about his chances today. They arriving at their polling station just before 9 a.m. As they left, Romney was asked who he voted for. "I...Read More

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    View the photo U.S. Vice President Biden holds hands with a poll worker as he emerges from the voting booth after casting his ballot during the U.S. presidential election in Greenville on Yahoo! News. Find more photos in our photo galleries.Read More

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    The first results of the 2012 election are in, and President Barack Obama and Mitt Romney are tied. As has been the tradition since 1960, residents of Dixville Notch, a tiny village in Coos County, New Hampshire, cast their ballots--all 1o of them--shortly after midnight Tuesday, with five votes for the president, and five for [...]Read More

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    Mitt Romney's seat on his campaign plane (Bedford MA)

    Mitt Romney's seat on his campaign plane (Bedford MA)

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    On the Romney press bus, @jimacostacnn does a live shot (Bedford MA)

    On the Romney press bus, @jimacostacnn does a live shot (Bedford MA)

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    US Air Force keeps fleet of aging warhorses flying

    TOKYO (AP) — For decades, the U.S. Air Force has grown accustomed to such superlatives as unrivaled and unbeatable. These days, some of its key combat aircraft are being described with terms like geriatric, or decrepit.

    The aging of the U.S. Air Force, a long-simmering topic in defense circles, made a brief appearance in the presidential debates when Republican nominee Mitt Romney cited it as evidence of the decline of U.S. military readiness. His contention that the Navy is the smallest it's been since 1917 got more attention, thanks to President Barack Obama's quip that the Navy also has fewer "horses and bayonets."

    But analysts say the Air Force has a real problem, and it will almost certainly worsen no matter who wins Tuesday's election. It was created in part by a lack of urgency in the post-Cold War era, and by design glitches and cost overruns that have delayed attempts to build next-generation aircraft.

    Looming budget cuts limit the force's ability to correct itself, they argue, as China's rise as a world power heightens its need to improve. And though the world's most formidable air force never had much use for bayonets, it's got more than its share of warhorses.

    ___

    IKE'S LEGACY — THE KC-135 STRATOTANKER

    The U.S. probably couldn't have fought the air wars over Iraq, Afghanistan and Libya without the KC-135 Stratotanker, the Air Force's main aerial refueler, which allows fighter jets to remain airborne on long flights.

    America has President Eisenhower to thank for that.

    The KC-135 came into service during his watch in 1956. The newest of the roughly 400 Stratotankers in service started flying nearly half a century ago, in 1964.

    "We are in unknown territory," said Lt. Col. Brian Zoellner, who has been flying the KC-135 for 15 years and is head of operations for 909th Air Refueling Squadron at Kadena Air Base on Japan's southwestern island of Okinawa. "The unknown is at what point does the KC-135 become unusable."

    The KC-46A refueling tanker is being developed as a replacement, but probably won't start delivery for another five years. If Congress has its way, some Stratotankers could still be taking off well into the 2040s.

    THAT '70s SHOW — THE F-15, F-16 AND A-10

    The F-15, America's workhorse warplane since the Vietnam War, was designed to have a service life of about 5,000 flight hours. The Air Force has more than tripled that, to 18,000 hours.

    The F-16, another key fighter, has been in use since 1979. The Air Force began retiring the oldest ones two years ago.

    Another '70s-era fighter is the A-10 Thunderbolt, which provides close air support for ground troops. It's now being rewinged because its old ones were riddled with cracks. The General Accounting Office estimates the cost of upgrading and refurbishing the aircraft will be $2.25 billion through 2013.

    The Air Force is revamping its fighter fleet with the stealthy F-22 Raptor and F-35 Joint Strike Fighter, but production of the F-22 was cut short after its price tag swelled to nearly half a billion dollars a pop. Delays and escalating costs have also dogged the F-35, which is now the most expensive Department of Defense procurement program ever.

    SPY PLANES FROM THE '50s — THE U-2

    The fabled U-2 "Dragon Lady" spy plane is still being used to keep watch over North Korea and other hot spots. The first U-2 flew in 1955, and the legendary Skunk Works aircraft became a household name for its role in the Cuban missile crisis, not to mention the propaganda bonanza the Soviet Union got by shooting one down in 1960 and capturing its CIA pilot, Francis Gary Powers.

    Many analysts argue the unmanned Global Hawk could do the job more effectively, but Congress has nixed that idea for now. More than $1.7 billion has been invested in upgrading the U-2.

    MAJOR KONG'S FAVORITE BOMBER — THE B-52

    Iconic, yes. State-of-the-art, no. The venerable B-52, remembered by movie fans for its starring role in the 1964 Cold War comedy "Dr. Strangelove," remains the backbone of the Air Force's strategic bomber force. It dates to 1954 and was already losing its edge by the end of the Vietnam War, but nearly 100 B-52s remain in service.

    The Air Force developed the B-1 in the 1970s as the B-52's replacement. President Jimmy Carter killed it, President Ronald Reagan brought it back, and none have been delivered since 1988.

    Next up was the stealth B-2 Spirit, which first flew in 1989. Because only 21 were built, they ended up costing a prohibitive $2 billion each. The Air Force is now hoping to upgrade with what it calls the Long Range Strike Bomber, but it's not clear when it will be ready.

    ___

    To be sure, all of these aircraft have undergone massive overhauls and updates, and most experts agree the U.S. Air Force remains the best-equipped in the world. Its aircraft aren't likely to soon start falling out of the sky, either, thanks to intensive, and expensive, maintenance.

    Zoellner, the KC-135 pilot, bristled at the idea his Stratotankers aren't safe. He said they "fly like a champ."

    But Loren Thompson, of the Lexington Institute, a conservative think tank, said the graying Air Force is evidence of how Washington has failed to keep its eye on the ball.

    "The reason the fleet is so decrepit is because for the first 10 years after the Cold War ended, policymakers thought the United States was in an era of extended peace," he said. "Then it spent the next 10 years fighting an enemy with no air force and no air defenses. So air power was neglected for 20 years, and today the Air Force reflects that fact."

    Former Air Force Col. Robert Haffa, a senior fellow at the Center for Strategic and Budgetary Assessments, added that although ground forces were the primary concern in Iraq and Afghanistan, air power will be a key to future security requirements as the United States turns its attention to the Pacific and a strengthening China.

    Unlike America's more recent adversaries, China has a credible air force that could conceivably strike U.S. bases in the region, requiring a deterrent force that is based farther away, out of range. America's bases in Japan — and possibly Guam — also are within striking distance of a North Korean missile attack.

    "As the nation looks to increased focus in the Pacific, these long-range strike platforms will be especially important," Haffa said. "Planes like the B-52 simply cannot survive."

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    Apple sells 3 million iPads since Friday

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